Most common drugs found in overdose deaths in 2016

Rank	Referent drug¹	Number of deaths²	Percent of deaths³
1	Fentanyl	18,335	28.8%
2	Heroin	15,961	25.1%
3	Cocaine	11,316	17.8%
4	Methamphetamine	6,762	10.6%
5	Alprazolam	6,209	9.8%
6	Oxycodone	6,199	9.7%
7	Morphine	5,014	7.9%
8	Methadone	3,493	5.5%
9	Hydrocodone	3,199	5.0%
10	Diazepam	2,022	3.2%

¹ Ranks were not tested for statistical significance.
² Number of drug overdose deaths involving the referent drug.
³ Percentage of drug overdose deaths involving the referent drug.
Note: Drug overdose deaths are identified using International Classification of Diseases, Tenth Revision underlying cause-of-death codes X40–X44 (unintentional), X60–X64 (suicide), and Y10–Y14 (undetermined). Only deaths with at least one specific drug identified are included in the analysis. The results for 110 deaths with an intent of homicide (X85) are not shown due to small numbers. Deaths may involve other drugs in addition to the referent drug (i.e., the one listed). Deaths involving more than one drug (e.g., a death involving both heroin and cocaine) are counted in both totals.

Source: CDC